The Human Eradication Army is a Beastmen organization formed by Lordgenome and led by the Four Supreme Generals, serving as the antagonists for the first half of Tengen Toppa Gurren Lagann. Its purpose is to keep the humans underground in order to prevent the human population from reaching one million and triggering the Anti-Spiral's Human Extermination System.

Members of the organization pilot Gunmen, which were originally designed to combat the Anti-Spiral. Its ranks are divided into four divisions, each led by a Supreme General, that patrols a separate sector of the planet to eliminate any humans who reach the surface.

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